One of the major things that Lizard falls on our part of human body and its predict our destiny?
There is any hopeful source said as truth like in Puranas or in Panjangams?
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I'm not sure if Puranas say such. But Gauli Sastra mentions the different omens or sakunas in detail. Gauli Sastra is prominent Sakuna system published with Panchangams or Astrology books in Andhra Pradesh, Karnataka and Tamilnadu.
Shri Ragavendra Rao (M.A in Astrology) from Tirupati Sri Venkteswara University translated the Telugu Manuscripts to English and published them in Saptarishi Astrology Magazine.
You can see the preserved Telugu Manuscripts of Gauli Sastra in above attached PDF.
Its has deep meaning. Its not limited to just body, i mean if lizard falls on your right hand, mouth, toes, everything has different meaning.
Also, different meaning for different gender. For example if lizard falls on lower lip of men, it will be financial loss for him, while if lizard falls on lower lip of women, it will bring positive results for her. Likewise, it has different meaning for all other body parts as well. Here is detail meaning for both men and women for their different body parts, published in Astrolaabh, do check out below.