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The big name weapons like Brahmastra are often neutralized by the same or similar weapon. When was the most damage inflicted by a single use of a weapon?

  • there are many but never used for big damage.. like Trishula (Trident) and Pashupatastra. I think Brahmastra caused most damage in a single use. – CR241 Jan 25 at 23:12
  • It depends what you define as "actual damage". The sundarsan chakra also eliminated powerful enemies. – Wikash_ Aug 11 at 17:03
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Indrajit employed Brahmastra by which Sixty seven crores of Vanaras were struck down in a single day.

सप्तषष्टिर्हताः कोट्यो वानराणां तरस्विनाम् | अह्नः पञ्चमशेषेण वल्लभेन स्वयम्भुवः || (Yuddha Kanda 74 Sarga 12 Sloka)

Sixty seven crores of powerful monkeys were struck down by the cherished missile of Brahma, the self-born creator, in the fifth and last period of the day.

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