Yes the rules that govern and duties to be followed by mankind depend on and differ according to the ages. See the following verses from the Manu Smriti:

 

> 1.84. The life of mortals, mentioned in the Veda, the desired results of sacrificial rites and the (supernatural) power of embodied
> (spirits) are fruits proportioned among men according to (the
> character of) the age.
> 
> 1.85. One set of duties (is prescribed) for men in the Krita age, different ones in the Treta and in the Dvapara, and (again) another
> (set) in the Kali, in a proportion as (those) ages decrease in length.
> 
> 1.86. In the Krita age the chief (virtue) is declared to be (the performance of) austerities, in the Treta (divine) knowledge, in the
> Dvapara (the performance of) sacrifices, in the Kali liberality alone.
 
So, for example, performing austerities, like they used to be performed in ancient times, are not suitable for people living in Kali Yuga. They need to adapt accordingly as prescribed.